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Check prices for these dates

Next weekend
21 Feb - 23 Feb
In two weeks
28 Feb - 2 Mar
In one month
14 Mar - 16 Mar
In two months
11 Apr - 13 Apr

Compare 163 Vacation Homes in St. Charles with updated reviews, rates, and availability.

Cheshire House // Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo Clinic
Living area

Cheshire House // Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo Clinic

10.0 out of 10, Exceptional, (36)
"This is a very comfortable home. I’m a patient at Mayo Clinic and need to be there every 2 weeks for a couple of months then every 12 weeks, we hope to book this house every time. Large backyard for our dog's and easy access to Mayo. The property owners are a blessing to work with. Easy to approach and very kind. Highly recommend their properties. "
Cheshire House // Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo Clinic
Elegant & Secure Family Abode Grand 4-Bedroom Retreat (Entire House)
Exterior

Elegant & Secure Family Abode Grand 4-Bedroom Retreat (Entire House)

10.0 out of 10, Exceptional, (5)
"Very comfortable and clean home with a lot of space. Very reasonably priced with everything you could need. Host was very accommodating and kind. Highly recommend this property."
Elegant & Secure Family Abode Grand 4-Bedroom Retreat (Entire House)
Bluffside cottage with gorgeous river views
View of Mississippi River from upper deck

Bluffside cottage with gorgeous river views

10.0 out of 10, Exceptional, (21)
"So cute/quiet/clean with gorgeous views of the river!"
Bluffside cottage with gorgeous river views
Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown
Home Front

Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown

10.0 out of 10, Exceptional, (28)
"The location was an easy jaunt to the hospital. The property was clean and cozy. Host was easy to communicate with. When we come back to Mayo this is definitely on my short list of houses I am more than happy to return to! "
Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown
Fresh space near Mayo Clinic and downtown
Living room, which is open to the dining room

Fresh space near Mayo Clinic and downtown

9.4 out of 10, Exceptional, (18)
"Very clean property. It was comfortable and cute. The owners were responsive to us and so helpful"
Fresh space near Mayo Clinic and downtown
Charming Brick Farmhouse with a Touch of Elegance. -Winona
Welcome to the Village House Inn. Whole house vacation rental.

Charming Brick Farmhouse with a Touch of Elegance. -Winona

10.0 out of 10, Exceptional, (120)
"Our family stayed at the Village House Inn over Christmas and it was perfect for accommodating a large group very comfortably. The location and proximity to Winona was also ideal. We will definitely be back! "
The price is AED 1,047
AED 1,727 total
includes taxes & fees
18 Feb - 19 Feb
Charming Brick Farmhouse with a Touch of Elegance. -Winona
Kutzky Cottage // 3 BR, 4 Blocks to Mayo, Family & Pet Friendly, Fenced Yard
Living area

Kutzky Cottage // 3 BR, 4 Blocks to Mayo, Family & Pet Friendly, Fenced Yard

10.0 out of 10, Exceptional, (11)
"I loved this house. It was easy to enter and everything was great."
Kutzky Cottage // 3 BR, 4 Blocks to Mayo, Family & Pet Friendly, Fenced Yard
Charming 3-bedroom, 2 bathroom house with outdoor space in Winona
Exterior

Charming 3-bedroom, 2 bathroom house with outdoor space in Winona

10.0 out of 10, Exceptional, (12)
"the inside was beautiful. the neighborhood was decent and quiet. very comfortable stay!"
The price is AED 863
AED 1,057 total
includes taxes & fees
18 Feb - 19 Feb
Charming 3-bedroom, 2 bathroom house with outdoor space in Winona
Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!
You'll have endless fun in our endless pool! Overlooks the Mississippi River!

Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!

10.0 out of 10, Exceptional, (65)
"The views are absolutely breathtaking! And the house itself, was more beautiful than the pictures could ever capture! The amenities were awesome and kept us busy! Definitely a 5 out of 5!! "
Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!
Historic City Hall Recorder's Office - ADA Accessible
Living Area

Historic City Hall Recorder's Office - ADA Accessible

2.0 star property
10.0 out of 10, Exceptional, (5)
"The historic building condo was a convenient and comfortable place to be during my 6 week stay in Rochester. "
The price is AED 250
AED 732 total
includes taxes & fees
20 Feb - 21 Feb
Historic City Hall Recorder's Office - ADA Accessible
RitaBNB 907 14th Unit #1 · Cozy 2BR close to Mayo (14#1)
Living area

RitaBNB 907 14th Unit #1 · Cozy 2BR close to Mayo (14#1)

8.0 out of 10, Very Good, (1)
"I needed a space for my pregnant daughter, her husband, and their toddler because their furnace died on Christmas Eve. I selected this property because it was reasonably priced and was rated as an "exceptional” property. The space is nice with good access to the Mayo Clinic. However, at the risk of getting a bad renter review, I do not think the property has earned its “exceptional” property rating.First, there were none of the extra’s you usually see at an "exceptional" property. There was no...
RitaBNB 907 14th Unit #1 · Cozy 2BR close to Mayo (14#1)
3 miles to Mayo, Four bed home, Covered By Faith
Front of house from street

3 miles to Mayo, Four bed home, Covered By Faith

2.0 star property
6.0 out of 10, (1)
"It was ok but when we came we had to clean first, and fix appliances which the tenants were very helpful with. "
3 miles to Mayo, Four bed home, Covered By Faith
☆Oakley's Oasis, a Dharma Dwellings Designed Home☆
Welcome to Oakley's Oasis! We look forward to hosting you!

☆Oakley's Oasis, a Dharma Dwellings Designed Home☆

10.0 out of 10, Exceptional, (29)
"Overall a comfy, cozy stay. Would consider returning with the only issue being we wish there was a king bed. The queen was a bit too cramped to be comfy."
☆Oakley's Oasis, a Dharma Dwellings Designed Home☆
Welcoming mid-century modern history-friendly home in bluff county.
This bright, romantic master is the perfect place to relax. Winter shown here.

Welcoming mid-century modern history-friendly home in bluff county.

10.0 out of 10, Exceptional, (21)
"House is clean and comfortable. Tammy is very easy to communicate with. The location is convenient to many areas of interest in the region. "
Welcoming mid-century modern history-friendly home in bluff county.
The River Cabin Summ
Nice size living room with amazing views of the Mississippi River

The River Cabin Summ

10.0 out of 10, Exceptional, (8)
"It was just beautiful!"
The River Cabin Summ
Century Cottage-PERFECT for Mayo & downtown visitors!
Cozy and spacious

Century Cottage-PERFECT for Mayo & downtown visitors!

10.0 out of 10, Exceptional, (107)
"Easy access to Mayo and the host was fantastic "
Century Cottage-PERFECT for Mayo & downtown visitors!
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
Welcome to Dee Dee's Den! We are pleased to offer this home for you!

☆Dee Dee's Den: A Dharma Dwellings Parent Company☆

10.0 out of 10, Exceptional, (29)
"The host was excellent and accomodating. We spent the weekend with a long time friend that is experiencing a difficult battle with cancer at the Mayo. The rental provided a comfortable worry free experience that provided an excellent central point for meeting up with others and providing access to local ammenties and attractions. "
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
Newly remodeled "Beach" Themed home that is close to downtown and Mayo Clinic.
Private kitchen

Newly remodeled "Beach" Themed home that is close to downtown and Mayo Clinic.

10.0 out of 10, Exceptional, (3)
"We were in Rochester for appointments at Mayo Clinic. Access to the Clinic was convenient. The house was clean and had everything we needed for our stay. We'll be back in March and plan to stay there again."
The price is AED 253
AED 694 total
includes taxes & fees
22 Feb - 23 Feb
Newly remodeled "Beach" Themed home that is close to downtown and Mayo Clinic.
Park in the Garage and Walk to Mayo Clinic
King size bed with memory foam mattress in primary bedroom located upstairs.

Park in the Garage and Walk to Mayo Clinic

10.0 out of 10, Exceptional, (54)
"Cozy house that quick and easy to get to and from the hospital. Easy access to restaurants and all the main amenities that you need. "
Park in the Garage and Walk to Mayo Clinic
Coratel Inn & Suites by Jasper Rochester-2 Queen Bed Non Smoking
Room

Coratel Inn & Suites by Jasper Rochester-2 Queen Bed Non Smoking

10.0 out of 10, Exceptional, (1)
"Room is very poorly lit. Not enough light sources, and they are dim."
The price is AED 264
AED 389 total
includes taxes & fees
18 Feb - 19 Feb
Coratel Inn & Suites by Jasper Rochester-2 Queen Bed Non Smoking
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in St. Charles

The Berkman
Lobby

The Berkman

3.0 star property
9.6 out of 10, Exceptional, (272)
"Stay was very enjoyable and staff were friendly and professional. "
The price is AED 578
AED 672 total
includes taxes & fees
2 Mar - 3 Mar
The Berkman
Big River Escape Riverside Cabins
Front of property

Big River Escape Riverside Cabins

3.0 star property
9.0 out of 10, Wonderful, (26)
"Quiet comfortable "
The price is AED 414
AED 437 total
includes taxes & fees
18 Feb - 19 Feb
Big River Escape Riverside Cabins
Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!
You'll have endless fun in our endless pool! Overlooks the Mississippi River!

Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!

10.0 out of 10, Exceptional, (65)
"The views are absolutely breathtaking! And the house itself, was more beautiful than the pictures could ever capture! The amenities were awesome and kept us busy! Definitely a 5 out of 5!! "
Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.