Find Luxury Hotels in Florence, SC

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Pick from 12 Florence Luxury Hotels and compare room rates, reviews, and availability. Most hotels are fully refundable.

The Mantissa Hotel
Exterior
The Mantissa Hotel
3.0 star property
9.2 out of 10, Wonderful, (214)
"Great rooms."
The price is AED 625
AED 700 total
includes taxes & fees
5 Dec - 6 Dec
The Mantissa Hotel
Days Inn by Wyndham Dillon
Business center
Days Inn by Wyndham Dillon
2.0 star property
5.4 out of 10, (678)
"Easy Access, Inexpensive. Clean sheets good TV . People are helpful."
The price is AED 219
AED 245 total
includes taxes & fees
25 Nov - 26 Nov
Days Inn by Wyndham Dillon
Hotel Florence, Tapestry Collection by Hilton
Exterior
Hotel Florence, Tapestry Collection by Hilton
3.0 star property
8.8 out of 10, Excellent, (533)
"😊"
The price is AED 490
AED 549 total
includes taxes & fees
12 Dec - 13 Dec
Hotel Florence, Tapestry Collection by Hilton
Days Inn by Wyndham Florence/I-95 North
Lobby
Days Inn by Wyndham Florence/I-95 North
2.0 star property
7.0 out of 10, Good, (1004)
"Great customer service."
The price is AED 209
AED 234 total
includes taxes & fees
1 Dec - 2 Dec
Days Inn by Wyndham Florence/I-95 North
Baymont Inn & Suites Florence by Wyndham
Exterior
Baymont Inn & Suites Florence by Wyndham
2.5 star property
5.6 out of 10, (1000)
"Still in Renovation mode "
Baymont Inn & Suites Florence by Wyndham
Clarion Inn & Suites
Exterior
Clarion Inn & Suites
2.5 star property
4.6 out of 10, (243)
"The staff went above and beyond to provide exceptional service and the room was extremely clean."
The price is AED 165
AED 185 total
includes taxes & fees
25 Nov - 26 Nov
Clarion Inn & Suites
Red Roof Inn Florence - Civic Center
Exterior
Red Roof Inn Florence - Civic Center
2.0 star property
6.8 out of 10, (1002)
"Water was out, but that was the city's issue. Your staff needs to be more customer friendly or find employment elsewhere. If you're behind the desk, your face should NOT be sour! SMILE and lose the attitude. "
The price is AED 223
AED 250 total
includes taxes & fees
1 Dec - 2 Dec
Red Roof Inn Florence - Civic Center
Days Inn by Wyndham Florence Near Civic Center
Pool
Days Inn by Wyndham Florence Near Civic Center
2.5 star property
6.6 out of 10, (1010)
"Property is easily accessible, close to restaurants and shopping, and in a safe area.Will be back."
The price is AED 200
AED 224 total
includes taxes & fees
26 Nov - 27 Nov
Days Inn by Wyndham Florence Near Civic Center
Quality Inn & Suites
Exterior
Quality Inn & Suites
2.5 star property
7.4 out of 10, Good, (614)
"Receiving was very friendly "
The price is AED 322
AED 361 total
includes taxes & fees
24 Nov - 25 Nov
Quality Inn & Suites
Quality Inn And Suites Civic
Exterior
Quality Inn And Suites Civic
2.5 star property
7.8 out of 10, Good, (1000)
"fast check in "
The price is AED 309
AED 346 total
includes taxes & fees
8 Dec - 9 Dec
Quality Inn And Suites Civic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Are you searching for the perfect hotel for your luxury holiday in Florence?
Expedia can help you get a flight to Florence, SC (FLO-Florence Regional) airport, and then you can select from a variety of places to stay that will deliver the luxury you seek. Amenities are an important consideration when you plan a vacation, so we make it easy to find what you’d like to make your stay special. If you want a posh hotel that has a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Florence offers. During your visit, you might want to enjoy the shopping which Florence is known for.
How many luxury hotels will I be able to find in Florence?
Lie in the lap of luxury during your getaway to Florence in one of Expedia’s 20 luxury hotels.
When can I expect good weather in Florence?
Planning for the weather is a good way to make your trip to Florence relaxing and enjoyable, especially when you’re splurging. The hottest months are usually July and August with an average temp of 78°F, while the coldest months are January and February with an average of 50°F. Average annual precipitation for Florence is 54 inches.
What's there to see and do in Florence?
Take in the sights and attractions that Florence offers with a visit to Florence Museum, Florence National Cemetery, and Magnolia Mall. If you have extra time while you’re in the area, you might want to stop by Florence Civic Center and Palmetto Shores Lake.
How can I get around Florence?
It’s easier to get around town in style when you know your options. If you want to venture outside of the area, hop aboard a train at Florence Station.