Photo by Isa
Find 4 Star Hotels in Santa Ana from AED 140
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Santa Ana 4 Star Hotels
Compare Santa Ana 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Crowne Plaza Panama Airport by IHG
Crowne Plaza Panama Airport by IHG
8.4 out of 10, Very Good, (2111)
The price is AED 437
AED 481 total
includes taxes & fees
5 May - 6 May

Decapolis Hotel Panama City
Decapolis Hotel Panama City
8.6 out of 10, Excellent, (1160)
The price is AED 341
AED 375 total
includes taxes & fees
27 Apr - 28 Apr

Riande Aeropuerto Hotel & Casino
Riande Aeropuerto Hotel & Casino
8.4 out of 10, Very Good, (1824)
The price is AED 395
AED 434 total
includes taxes & fees
26 Apr - 27 Apr

Sheraton Grand Panama
Sheraton Grand Panama
8.6 out of 10, Excellent, (864)
The price is AED 468
AED 515 total
includes taxes & fees
2 May - 3 May

Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica
9.6 out of 10, Exceptional, (999)
The price is AED 360
AED 396 total
includes taxes & fees
30 Apr - 1 May

Marriott Panama Hotel
Marriott Panama Hotel
9.0 out of 10, Wonderful, (1001)
The price is AED 493
AED 542 total
includes taxes & fees
2 May - 3 May

Novotel Panama City
Novotel Panama City
9.0 out of 10, Wonderful, (1005)
The price is AED 287
AED 315 total
includes taxes & fees
11 May - 12 May

Megapolis Hotel Panamá
Megapolis Hotel Panamá
8.4 out of 10, Very Good, (868)
The price is AED 467
AED 513 total
includes taxes & fees
26 Apr - 27 Apr
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Santa Ana.

Hotel Riu Plaza Panama
Calle 50, Urb. Marbella, Panama City, Panama
The price is AED 459 per night from Apr 29 to Apr 30
AED 459
AED 505 total
includes taxes & fees
29 Apr - 30 Apr
9/10 Wonderful! (3,851 reviews)
Still don't see what you're looking for?
See all properties in Santa Ana.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Santa Ana
Trip time! Discover the parks and museums in Santa Ana.

Photo by Isa
Open Photo by Isa
Recent reviews of Santa Ana hotels
Recent reviews of Santa Ana hotels

Novotel Panama City
5/5 Excellent
"Love it. "
A verified traveler stayed at Novotel Panama City
Posted 3 days ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Santa Ana Hotels by Star Rating
Hotels in Santa Ana Neighborhoods
Stay near popular Santa Ana attractions
- Hotels near Avenida Central
- Hotels near Albrook Shopping Mall
- Hotels near Multiplaza Pacific Mall
- Hotels near Amador Causeway
- Hotels near Avenida Balboa
- Hotels near Cinta Costera
- Hotels near Via Espana
- Hotels near Fuerte Amador Resort & Marina
- Hotels near El Dorado Mall
- Hotels near Veracruz Beach
- Hotels near Miraflores Locks
- Hotels near Gamboa Rainforest Resort
- Hotels near Metromall Panama
- Hotels near Panama Viejo
- Hotels near Uruguay Street
- Hotels near ATLAPA Conventions Center
- Hotels near Isla Taboga Pier
- Hotels near Los Pueblos Commercial Center
- Hotels near Iglesia del Carmen
- Hotels near Calle 50
More Hotel Options in Santa Ana
Explore more hotels
- Marriott Panama Hotel
- W Panama
- Ramada Plaza By Wyndham Panama Punta Pacífica
- The Executive Hotel
- Novotel Panama City
- Megapolis Hotel Panamá
- Decapolis Hotel Panama City
- TRYP by Wyndham Panamá Centro
- Hotel Ojos del Rio
- Las Americas Golden Tower Panama
- Riande Aeropuerto Hotel & Casino
- Waldorf Astoria Panama
- Sofitel Legend Casco Viejo, Panama City
- Hospedium Princess Hotel Panama
- Central Hotel Panama Casco Viejo
- Studio Coliving
- Bristol Panama, a Registry Collection Hotel
- Exe Oriental Panama
- Holiday Inn Panama Distrito Financiero by IHG
- The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City