Search Vacation Homes in Southeast Minnesota

    calendar shield illustration
    Change your mind
    Book hotels with free cancellation
    deals illustration
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    bed illustration
    Be picky
    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks
In one month
In two months

Compare 333 Vacation Homes in Southeast Minnesota with updated reviews, rates, and availability.

Charming 1-bedroom house in delightful Winona with WiFi, AC and PRIVATE PATIO

10.0 out of 10, Exceptional, (5)
Charming 1-bedroom house in delightful Winona with WiFi, AC and PRIVATE PATIO

The dollar house

10.0 out of 10, Exceptional, (28)
"Absolutely lovely place to stay. We enjoyed stay there very much. "
The dollar house

The Tangerine Terrace - Charming 4-bedroom house in Red Wing with two king beds

The Tangerine Terrace - Charming 4-bedroom house in Red Wing with two king beds

Rural Winona Co. Guest House Getaway: Relax and Enjoy the Simple Things in Life

10.0 out of 10, Exceptional, (39)
"The house is spacious and clean and the scenery was great!!"
Rural Winona Co. Guest House Getaway: Relax and Enjoy the Simple Things in Life

Century Cottage-PERFECT for Mayo & downtown visitors!

10.0 out of 10, Exceptional, (111)
"We were in Rochester for a visit to Mayo. The Cottage is within 1.2 miles and it's a very easy commute. The Cottage itself is very comfortable and homey. Great place to relax after appointments/surgery. The owners are very responsive/helpful and the chickens are amazing! "
Century Cottage-PERFECT for Mayo & downtown visitors!

Charming 3-bedroom LakeHouse with WiFi and AC in delightful Waterville

10.0 out of 10, Exceptional, (1)
"Great communication. Very easy to work with!"
The price is AED 918
AED 1,692 total
includes taxes & fees
28 Apr - 29 Apr
Charming 3-bedroom LakeHouse with WiFi and AC in delightful Waterville

The BRD Nest Mississippi River views backdropped by majestic Minnesota bluffs

10.0 out of 10, Exceptional, (45)
"Lots of beds and bathrooms to share the weekend with extended family."
The BRD Nest Mississippi River views backdropped by majestic Minnesota bluffs

Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown

10.0 out of 10, Exceptional, (37)
"Would stay again! Thank you!"
Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown

Cozy 4 bedroom relax atmosphere enjoy beauty of bluff country driftless region

10.0 out of 10, Exceptional, (17)
"Cozy place, Lisa made it very welcoming for Xmas"
Cozy 4 bedroom relax atmosphere enjoy beauty of bluff country driftless region

1 mi. from Mayo Clinic; Cozy, Clean

9.6 out of 10, Exceptional, (90)
"This was a great place to stay, as advertised conveniently located and quiet"
1 mi. from Mayo Clinic; Cozy, Clean

Entertainment for the whole family. Sleeps up to 10.

10.0 out of 10, Exceptional, (2)
"The house was very clean, with everything you needed. I loved the cinema and the communication with the owner, who was excellent, very friendly. I sincerely recommend it. The area was very quiet."
Entertainment for the whole family. Sleeps up to 10.

Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly

9.8 out of 10, Exceptional, (57)
"Everything about this Vrbo was excellent. My family raved about the lay-out, location and access to everything. It really felt like we were returning home everytime we pulled in. "
Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly

Golf view!

9.8 out of 10, Exceptional, (40)
"We will definitely be back again! "
Golf view!

Happy Days Log Home and garden on Fountain Lake. Toys for all!

10.0 out of 10, Exceptional, (37)
"Couldn't ask for a better place!"
Happy Days Log Home and garden on Fountain Lake. Toys for all!

Bluffside cottage with gorgeous river views

10.0 out of 10, Exceptional, (26)
"So cute/quiet/clean with gorgeous views of the river!"
Bluffside cottage with gorgeous river views

Fresh space near Mayo Clinic and downtown

9.4 out of 10, Exceptional, (18)
"Very clean property. It was comfortable and cute. The owners were responsive to us and so helpful"
Fresh space near Mayo Clinic and downtown

Villa Serra - Lakehouse in Pepin

10.0 out of 10, Exceptional, (56)
"Loved the location and the views!"
Villa Serra - Lakehouse in Pepin

Magical Nest Hideaway

10.0 out of 10, Exceptional, (113)
"The wild turkeys and deer who greeted us in the morning. "
Magical Nest Hideaway

Luxury Stay/ Theater / Pool Table / Dogs Welcome

2.0 star property
10.0 out of 10, Exceptional, (7)
"Great place"
Luxury Stay/ Theater / Pool Table / Dogs Welcome

Within walking distance of all the amenities! Bike the trail~ float the river

10.0 out of 10, Exceptional, (11)
"The house was great! Kitchen is well stocked and we felt right at home. We would love to come back again!"
Within walking distance of all the amenities! Bike the trail~ float the river
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Southeast Minnesota
Save an average of 15% on thousands of hotels when you're signed in

Other property types in Southeast Minnesota

The Berkman

3.0 star property
9.6 out of 10, Exceptional, (285)
"Great Place."
The price is AED 389
AED 452 total
includes taxes & fees
16 May - 17 May
The Berkman

Big River Escape Riverside Cabins

3.0 star property
9.0 out of 10, Wonderful, (28)
"Great location. We are here for fishing the river. We would so stay here again! Very nice! River Ratze bar and restaurant was nice! And SO close!"
The price is AED 376
AED 396 total
includes taxes & fees
28 Apr - 29 Apr
Big River Escape Riverside Cabins

Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!

10.0 out of 10, Exceptional, (68)
"Perfect for a family get away. Kids loved the pool. "
Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.