South Main Vacations

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Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Discovery Green which includes a city, central business district and a high rise building

Downtown Houston

3 out of top 10 points of interest in this area

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

Find hotels in Downtown Houston

South Main Hotel Deals

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center
3.5 out of 5
8686 Kirby Drive, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AED 510 per night from Mar 24 to Mar 25
AED 510
AED 597 total
includes taxes & fees
24 Mar - 25 Mar
7.2/10 Good! (1,001 reviews)
Handicapped shower
"Odd shower, kept getting water everywhere as it was a handicap bathroom (despite us not being handicapped) so kept running out of towels and the floor was always wet"

Reviewed on 17 February 2025

Wyndham Houston near NRG Park/Medical Center
Comfort Suites near Texas Medical Center - NRG Stadium
Comfort Suites near Texas Medical Center - NRG Stadium
2.5 out of 5
1055 Mcnee Rd, Houston, TX
The price is AED 380 per night from Mar 27 to Mar 28
AED 380
AED 445 total
includes taxes & fees
27 Mar - 28 Mar
8.4/10 Very Good! (788 reviews)
"Always stay here for price and convenience"

Reviewed on 27 February 2025

Comfort Suites near Texas Medical Center - NRG Stadium
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4 out of 5
5353 Westheimer Rd, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AED 447 per night from Apr 4 to Apr 5
AED 447
AED 527 total
includes taxes & fees
4 Apr - 5 Apr
8/10 Very Good! (1,800 reviews)
"yy"

Reviewed on 3 March 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
See all 6,387 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in South Main

At the main entrance.

Toyota Center

4/5(967 reviews)

Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed art scene and entertainment choices in this vibrant area.

Toyota Center
Close to the entrance of convention center.

George R. Brown Convention Center

4/5(961 reviews)

During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the great live music and lively festivals in this vibrant area.

George R. Brown Convention Center
Rice University

Rice University

4.5/5(356 reviews)

Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's acclaimed theater scene and lively festivals.

Rice University