South Main Vacations

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Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Discovery Green which includes a city, central business district and a high rise building

Downtown Houston

3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

Find hotels in Downtown Houston

South Main Hotel Deals

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center
3.5 out of 5
8686 Kirby Drive, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AED 511 per night from Apr 22 to Apr 23
AED 511
AED 597 total
includes taxes & fees
22 Apr - 23 Apr
7.2/10 Good! (1,022 reviews)
Great Stay
"Hotel was comfortable. Location was right beside a major freeway. Freeway noise was very loud but the comfort of the room made up for the noise. Will stay again but will request a room on the back of the hotel."

Reviewed on 17 April 2025

Wyndham Houston near NRG Park/Medical Center
Club Quarters Hotel Downtown, Houston
Club Quarters Hotel Downtown, Houston
4 out of 5
1085 Rusk Street, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AED 393 per night from Apr 22 to Apr 23
AED 393
AED 460 total
includes taxes & fees
22 Apr - 23 Apr
8.2/10 Very Good! (3,258 reviews)
"Stay was great. Walking distance to Daikin Park and food, drinks, music, bars, shopping conveniently located a block away from hotel."

Reviewed on 17 April 2025

Club Quarters Hotel Downtown, Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4 out of 5
5353 Westheimer Rd, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AED 526 per night from May 10 to May 11
AED 526
AED 620 total
includes taxes & fees
10 May - 11 May
8/10 Very Good! (1,969 reviews)
"Always loved this hotel"

Reviewed on 17 April 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
See all 6,233 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in South Main

Close to the entrance of convention center.

George R. Brown Convention Center

4/5(961 reviews)

During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area.

George R. Brown Convention Center
At the main entrance.

Toyota Center

4/5(967 reviews)

Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area.

Toyota Center
Friday night fireworks.

Daikin Park

4.5/5(907 reviews)

Catch an event at Daikin Park during your trip to Houston. Experience the entertainment choices and lively festivals in this vibrant area.

Daikin Park