Otay Mesa Vacations

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Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
US Grant Hotel

Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Otay Mesa Hotel Deals

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AED 388 per night from May 6 to May 7
AED 388
AED 446 total
includes taxes & fees
6 May - 7 May
7.8/10 Good! (1,498 reviews)
"Great comfortable helpful staff clean breakfast area was great !"

Reviewed on 19 April 2025

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AED 694 per night from Apr 21 to Apr 22
AED 694
AED 948 total
includes taxes & fees
21 Apr - 22 Apr
8.2/10 Very Good! (1,176 reviews)
"Nice facility. Would stay there again."

Reviewed on 17 April 2025

San Diego Mission Bay Resort
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AED 568 per night from May 12 to May 13
AED 568
AED 659 total
includes taxes & fees
12 May - 13 May
8.2/10 Very Good! (5,677 reviews)
"This property was close to train station and within walking distance to whatever we needed. Staff was very friendly. Property clean. One downfall was the rooms that face the train station were very noisy from the traffic, emergency vehicles and trains. Would definitely stay at this location again ..."

Reviewed on 19 April 2025

Wyndham San Diego Bayside
See all 4,619 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Otay Mesa

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

4.5/5(3,565 reviews)

Why not visit the animals who live at San Diego Zoo and see why this is a favorite attraction in San Diego? Stroll along the area's seaside or experience its acclaimed theater scene.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

4.5/5(1,297 reviews)

During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and acclaimed art scene.

San Diego Convention Center
Mission Bay featuring a sandy beach

Mission Bay

4.5/5(2,386 reviews)

Explore the great outdoors at Mission Bay, a popular spot to commune with nature in San Diego. Stroll along the seaside in this family-friendly area, or check out its top-notch restaurants.

Mission Bay