Find hotels near Main Street Hyannis, Hyannis from AED 246
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Compare 3,505 hotels close to Main Street Hyannis with room rates, reviews, and availability. Most hotels are fully refundable.

Sea Street Inn
Sea Street Inn
10.0 out of 10, Exceptional, (39)
The price is AED 887
AED 1,015 total
includes taxes & fees
18 Mar - 19 Mar

Anchor In Distinctive Waterfront Lodging
Anchor In Distinctive Waterfront Lodging
9.4 out of 10, Exceptional, (1003)
The price is AED 467
AED 700 total
includes taxes & fees
18 Mar - 19 Mar

Hampton Inn & Suites Cape Cod-West Yarmouth
Hampton Inn & Suites Cape Cod-West Yarmouth
9.0 out of 10, Wonderful, (1002)
The price is AED 342
AED 392 total
includes taxes & fees
23 Mar - 24 Mar

Hyannis Inn
Hyannis Inn
8.6 out of 10, Excellent, (981)
The price is AED 388
AED 444 total
includes taxes & fees
25 Mar - 26 Mar

The Cove At Yarmouth
The Cove At Yarmouth
9.2 out of 10, Wonderful, (227)
The price is AED 483
AED 553 total
includes taxes & fees
18 Mar - 19 Mar

Courtyard By Marriott Cape Cod Hyannis
Courtyard By Marriott Cape Cod Hyannis
8.8 out of 10, Excellent, (449)
The price is AED 403
AED 461 total
includes taxes & fees
23 Mar - 24 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Hotels near Other Hyannis Attractions
Hotels near Other Hyannis Attractions

John F. Kennedy Hyannis Museum
4.5/5(137 reviews)
You can spend an afternoon browsing the exhibits at John F. Kennedy Hyannis Museum during your trip to Hyannis. Wander the beautiful beaches and waterfront in this family-friendly area.
Recent reviews of Main Street Hyannis hotels
Recent reviews of Main Street Hyannis hotels

Margaritaville Resort Cape Cod
5/5 Excellent
"We loved "
A verified traveler stayed at Margaritaville Resort Cape Cod
Posted 4 days ago
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Hotels near popular Hyannis Attractions
- Hotels near John F. Kennedy Hyannis Museum
- Hotels near Hyannis Harbor
- Hotels near Cape Cod Melody Tent
- Hotels near Mayflower Beach
- Hotels near Cape Cod Inflatable Park
- Hotels near Harwich Port
- Hotels near West Dennis Beach
- Hotels near Craigville Beach
- Hotels near Sandy Neck Beach
- Hotels near Seagull Beach
- Hotels near Cape Cod Rail Trail
- Hotels near Mashpee Commons
- Hotels near Corporation Beach
- Hotels near Sea Street Beach
- Hotels near Kalmus Beach
- Hotels near John F. Kennedy Memorial
- Hotels near Barnstable Harbor
- Hotels near Cape Cod Baseball Hall of Fame
- Hotels near Breakwater Beach
- Hotels near Grays Beach
Other Hotels near Main Street Hyannis, Hyannis
- Cape Cod Hotels
- Hyannis Hotels
- Martha's Vineyard Hotels
- Chatham Hotels
- Plymouth Hotels
- Falmouth Hotels
- East Sandwich Hotels
- Dennis Port Hotels
- Edgartown Hotels
- Brewster Hotels
- South Yarmouth Hotels
- West Yarmouth Hotels
- Wellfleet Hotels
- Eastham Hotels
- Oak Bluffs Hotels
- Dennis Hotels
- Orleans Hotels
- Harwich Hotels
- Sandwich Hotels
- East Falmouth Hotels
More Hotel Options in Main Street Hyannis
- Adventure Hotels
- Beach Hotels
- Business Hotels
- Cheap Hotels
- Family Hotels
- Golf Hotels
- Hotel Wedding Venues
- Hotel with a Concierge
- Hotels with Bars
- Hotels with Free Parking
- Hotels with Hot Tubs
- Hotels with Waterslides
- Hotels with WiFi
- Hotels with a Pool
- Hotels with an Indoor Pool
- Hotels with smoking rooms
- Resorts & Hotels with Spas
- Shopping Hotels
- Waterpark Hotels
- Winery Hotels
Explore more hotels
- Hyannis Harbor Hotel
- Americas Best Value Inn & Suites Hyannis Cape Cod
- Hampton Inn & Suites Cape Cod-West Yarmouth
- Colonial Acres Resort
- Charming Updated Cape Home! Sleeps 12! Location!
- Hyannis Plaza Hotel
- Doubletree by Hilton Cape Cod - Hyannis
- SPACIOUS HOME w/CENTRAL A/C & PRIVATE FENCED IN HALF ACRE YARD. WALK TO ALL..
- Waterfront 5-Bed 2-Bath Retreat
- Walk to Beach & Main Street: Hyannis Cottage
- MINS TO BEACHES WALK TO DOWNTOWN, HARBOR & SHOPS NICE FENCED YARD - A/C & WiFi
- 2 bed 2 bath house in Hyannis walk to beach, Harbor, Main st, pet friendly fence