South Main, TX

Houston

Photo by Hazem Abdul

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South Main Hotel Deals

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center
3.5 out of 5
8686 Kirby Drive, Houston, TX
The price is AED 511 per night from Apr 22 to Apr 23
AED 511
AED 597 total
includes taxes & fees
22 Apr - 23 Apr
Stay at this 3.5-star business-friendly hotel in Houston. Enjoy free WiFi, a 24-hour fitness center, and a 24-hour front desk. Our guests praise the helpful ...
7.2/10 Good! (1,022 reviews)
Great Stay
"Hotel was comfortable. Location was right beside a major freeway. Freeway noise was very loud but the comfort of the room made up for the noise. Will stay again but will request a room on the back of the hotel."

Reviewed on 17 April 2025

Wyndham Houston near NRG Park/Medical Center
Club Quarters Hotel Downtown, Houston
Club Quarters Hotel Downtown, Houston
4 out of 5
1085 Rusk Street, Houston, TX
The price is AED 393 per night from Apr 22 to Apr 23
AED 393
AED 460 total
includes taxes & fees
22 Apr - 23 Apr
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful ...
8.2/10 Very Good! (3,258 reviews)
"Stay was great. Walking distance to Daikin Park and food, drinks, music, bars, shopping conveniently located a block away from hotel."

Reviewed on 17 April 2025

Club Quarters Hotel Downtown, Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4 out of 5
5353 Westheimer Rd, Houston, TX
The price is AED 526 per night from May 9 to May 10
AED 526
AED 620 total
includes taxes & fees
9 May - 10 May
Stay at this hotel in Houston. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,980 reviews)
"All good except to crowded for the amount of elevators!"

Reviewed on 20 April 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
The Whitehall Houston
The Whitehall Houston
4 out of 5
1700 Smith St, Houston, TX
The price is AED 467 per night from May 18 to May 19
AED 467
AED 547 total
includes taxes & fees
18 May - 19 May
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,280 reviews)
"I liked the valet parking and available shuttle to different areas in downtown Houston."

Reviewed on 19 April 2025

The Whitehall Houston
Sonesta Hotel Houston IAH Airport
Sonesta Hotel Houston IAH Airport
4 out of 5
425 North Sam Houston Parkway East, Houston, TX
The price is AED 426 per night from Apr 22 to Apr 23
AED 426
AED 499 total
includes taxes & fees
22 Apr - 23 Apr
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
7.4/10 Good! (1,003 reviews)
"Clean environment, friendly staff"

Reviewed on 15 April 2025

Sonesta Hotel Houston IAH Airport
Blossom Hotel Houston
Blossom Hotel Houston
4 out of 5
7118 Bertner Ave, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AED 541 per night from Apr 27 to Apr 28
AED 541
AED 632 total
includes taxes & fees
27 Apr - 28 Apr
Stay at this 4-star spa hotel in Houston. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (3,242 reviews)
"Very Beautiful! And very nice customer service"

Reviewed on 18 April 2025

Blossom Hotel Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around South Main

#race

Astrodome

4/5(276 area reviews)

If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Astrodome and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.

Astrodome
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Texas Medical Center

4/5(566 area reviews)

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Texas Medical Center
Hermann Park featuring landscape views and a park

Houston Museum District

Known for its ample dining options and fascinating museums, there's plenty to explore in Houston Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at M. D. Anderson Station or Museum District Station to see more of the city.

Houston Museum District
Hermann Park featuring landscape views and a park

South Central Houston

4.5/5(74 area reviews)

If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.

South Central Houston
Menil Collection which includes art and interior views

Montrose

4/5(128 area reviews)

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.

Montrose
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Greater Third Ward

4/5(23 area reviews)

While you're in Greater Third Ward, take in top sights like Fertitta Center or TDECU Stadium, and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.

Greater Third Ward

South Main, TX

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