Visit South Main
Popular places to visit

George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area.

Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area.

Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the entertainment choices and lively festivals in this vibrant area.

NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.

Rice University
Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's lively festivals and fascinating museums.

Space Center Houston
Study the exhibits at Space Center Houston, a favorite museum in Houston. Amble around the area's lakeside or attend a sporting event.
South Main Hotel Deals

Reviewed on 17 April 2025

Reviewed on 17 April 2025

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Reviewed on 18 April 2025
Other neighborhoods around South Main

Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Astrodome and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.

Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Houston Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Houston Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at M. D. Anderson Station or Museum District Station to see more of the city.

South Central Houston
If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.

Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.

Greater Third Ward
While you're in Greater Third Ward, take in top sights like Fertitta Center or TDECU Stadium, and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
- NRG Stadium
- MD Anderson Cancer Center
- Toyota Center
- George R. Brown Convention Center
- Daikin Park
- Rice University
- University of Houston
- Memorial City Mall
- Houston Zoo
- NRG Park
- Downtown Aquarium
- Westheimer Rd
- CityCentre
- Smart Financial Centre at Sugar Land
- Sugar Land Town Square
- Discovery Green
- Golf Club of Houston
- Sam Houston Race Park
- NRG Center
- Hermann Park
- House of Blues Houston
- Houston Natural Science Museum
- Baybrook Mall
- Hobby Center for the Performing Arts
- Pearland Town Center
- Lakewood Church
- The Galleria
- Texas Children's Hospital
- Texas Southern University
- Greenway Plaza
- Houston Methodist Hospital
- Memorial Park