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Compare 122 Vacation Homes in Byron with updated reviews, rates, and availability.

Century Cottage-PERFECT for Mayo & downtown visitors!
Cozy and spacious

Century Cottage-PERFECT for Mayo & downtown visitors!

10.0 out of 10, Exceptional, (102)
"We had a girls weekend and did some baking and shopping"
Century Cottage-PERFECT for Mayo & downtown visitors!
Park in the Garage and Walk to Mayo Clinic
King size bed with memory foam mattress in primary bedroom located upstairs.

Park in the Garage and Walk to Mayo Clinic

10.0 out of 10, Exceptional, (52)
"Have had to come up to Mayo twice for appointments and stayed here both times. Place makes you feel at home very comfortable and cozy. Large kitchen plenty of space. Bed is amazing and cozy. Host was easy to communicate with and very nice. "
Park in the Garage and Walk to Mayo Clinic
Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.
Exterior detail

Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.

10.0 out of 10, Exceptional, (63)
"Enjoyed 3 nights at this lovely home as my husband recovered from sugery at Mayo. The beds and all the living room furniture was exceedingly comfortable. The host responded immediately to any questions. The hospital is a quick walk, but here's a bonus: Starbucks is a mere two minute walk from the home. I highly recommend this experience of staying in this cozy home away from home."
Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.
Coratel Inn & Suites by Jasper Rochester-2 Queen Bed Non Smoking
Room

Coratel Inn & Suites by Jasper Rochester-2 Queen Bed Non Smoking

The price is AED 253
AED 376 total
includes taxes & fees
1 Jan - 2 January 2025
Coratel Inn & Suites by Jasper Rochester-2 Queen Bed Non Smoking
City Hall Recorder's Office
Living Area

City Hall Recorder's Office

2.0 star property
10.0 out of 10, Exceptional, (3)
"Property is just as stated and was n walking distance to Mayo and places to eat. The apartment had everything someone would need. Management sent good efficient communication regarding check in and out process."
The price is AED 334
AED 829 total
includes taxes & fees
31 Jan - 1 February 2025
City Hall Recorder's Office
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
Welcome to Dee Dee's Den! We are pleased to offer this home for you!

☆Dee Dee's Den: A Dharma Dwellings Parent Company☆

10.0 out of 10, Exceptional, (27)
"We had a great time"
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
Great Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo
Living area

Great Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo

10.0 out of 10, Exceptional, (32)
"Well maintained , clean, close to Mayo Clinic. Great host to work with the only thing I would complain about is it’s so nice. I don’t want to lose it when we go back. Ha ha! We’ve been there twice and we will keep coming back. Great place to stay if you’re a Mayo Clinic patient"
Great Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo
Charming 2 Bed 1 Bath Home W/Fully Fenced in Back yard
Living area

Charming 2 Bed 1 Bath Home W/Fully Fenced in Back yard

9.4 out of 10, Exceptional, (13)
"Everything was excellent! Super happy"
The price is AED 496
AED 1,209 total
includes taxes & fees
31 Jan - 1 February 2025
Charming 2 Bed 1 Bath Home W/Fully Fenced in Back yard
Fresh space near Mayo Clinic and downtown
Living room, which is open to the dining room

Fresh space near Mayo Clinic and downtown

9.6 out of 10, Exceptional, (16)
"Very clean property. It was comfortable and cute. The owners were responsive to us and so helpful"
Fresh space near Mayo Clinic and downtown
Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly
Eat-in kitchen

Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly

9.8 out of 10, Exceptional, (52)
"We had to gather a lot of family on short notice to say goodbye to a dying family member and this space was perfect for us all to gather and grieve together. There was plenty of sleeping space for everyone and it was conveniently lovlcated near parks and walking trails for our kiddos."
Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly
Modern Gem. Close to Mayo. Office and Fast Internet
Entertainment in living room with dinning space

Modern Gem. Close to Mayo. Office and Fast Internet

9.2 out of 10, Wonderful, (7)
"Fun"
Modern Gem. Close to Mayo. Office and Fast Internet
☆Oakley's Oasis, a Dharma Dwellings Designed Home☆
Welcome to Oakley's Oasis! We look forward to hosting you!

☆Oakley's Oasis, a Dharma Dwellings Designed Home☆

10.0 out of 10, Exceptional, (29)
"I brought my mother to Rochester for a procedure and the home was quite nice. Hard wood floors and comfortable accommodations. It was 20 below with the wind and yet stayed warm. Communication was quick and helpful. I would strongly recommend if you need a place to stay. 👍"
☆Oakley's Oasis, a Dharma Dwellings Designed Home☆
Charming 4-bedroom house with 3 king/1 full beds, 2 full baths, AC, Wifi, Patio
Exterior

Charming 4-bedroom house with 3 king/1 full beds, 2 full baths, AC, Wifi, Patio

10.0 out of 10, Exceptional, (1)
"Thank you, great place to stay if you want to be near the mayo. Also very close to the mall and other stores. Place was very well maintained and clean. Would recommend again."
Charming 4-bedroom house with 3 king/1 full beds, 2 full baths, AC, Wifi, Patio
3 miles to Mayo, Four bed home, Covered By Faith
Front of house from street

3 miles to Mayo, Four bed home, Covered By Faith

2.0 star property
6.0 out of 10, (1)
3 miles to Mayo, Four bed home, Covered By Faith
"Walden Pond" Adventure Amidst 44 Private Acres
Enjoy the comfort and beauty of the inside and the awesome adventure outside.

"Walden Pond" Adventure Amidst 44 Private Acres

10.0 out of 10, Exceptional, (121)
"N"
"Walden Pond" Adventure Amidst 44 Private Acres
Lost Creek Executive Home on 200 acre horse Ranch w/Trout Stream
Property grounds

Lost Creek Executive Home on 200 acre horse Ranch w/Trout Stream

9.8 out of 10, Exceptional, (6)
"This home was AMAZING and there was so much space. If it had more Beds, Futons or Couches available for LARGE GROUPS it could really bring in the bigger groups since the Mayo Civic Center is only 20 Minutes away. If you are looking for a great accommodating host and an amazing property...LOK NO FURTHER."
Lost Creek Executive Home on 200 acre horse Ranch w/Trout Stream
BIG Discount! Five Star-3 Bedroom Showstopper 4 Minutes to Mayo Clinic!
Relax in our stylishly decorated living room.

BIG Discount! Five Star-3 Bedroom Showstopper 4 Minutes to Mayo Clinic!

9.6 out of 10, Exceptional, (10)
"We celebrated our family “Thanksmas” with my daughter’s uncle and his family here. It was a very quick trip but the layout of the house with the three bedrooms, generous kitchen and dining table were perfect for our needs. The 2-year old especially was enamored with the numerous toys provided and the older girls were able to do lots of crafts and games at the dining table. As the oldest adult, I appreciated the comfort of the bed and how clean and organized the entire place was. The little...
BIG Discount! Five Star-3 Bedroom Showstopper 4 Minutes to Mayo Clinic!
Charming 2-Bedroom house along city trail 1 mile from Mayo Clinic and downtown.
Dinning room seats 6

Charming 2-Bedroom house along city trail 1 mile from Mayo Clinic and downtown.

9.8 out of 10, Exceptional, (40)
"Great option for being able to cook our own meals and have some privacy versus a hotel option. Everything we needed for our family. Thank you!"
Charming 2-Bedroom house along city trail 1 mile from Mayo Clinic and downtown.
Euro House, Spacious! Near Mayo-Private Home
Open concept, architecturally pleasing, soft and modern roomy home.

Euro House, Spacious! Near Mayo-Private Home

10.0 out of 10, Exceptional, (34)
"Very comfortable modern unit. Kitchen was well equipped and supplied and easy to work in. Downstairs bathroom great accessibility; ground floor very pretty but not as accessible. We enjoyed ourcstay."
Euro House, Spacious! Near Mayo-Private Home
Magical Nest Hideaway
Bathroom

Magical Nest Hideaway

10.0 out of 10, Exceptional, (108)
"What an amazing little hideaway! It was in a beautiful neighborhood and perfect for our visit to Mayo. It was the perfect size for the both of us. We will be back!!"
Magical Nest Hideaway
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Byron

The Berkman
Lobby

The Berkman

3.0 star property
9.6 out of 10, Exceptional, (260)
"Clean & enjoyable stay. "
The Berkman
Broadway Plaza, Trademark Collection by Wyndham
Room

Broadway Plaza, Trademark Collection by Wyndham

3.0 star property
9.2 out of 10, Wonderful, (147)
"Very good"
Broadway Plaza, Trademark Collection by Wyndham
Valley Cabin
Exterior

Valley Cabin

9.0 out of 10, Wonderful, (6)
"This is a great property. Peaceful, surrounded by fields & forests, birds singing, and fresh air. Wonderful parks and trails near by. Dan was a great host. I want to come back and stay in the fall and winter. This would also be a great place for a family get away"
The price is AED 220
AED 489 total
includes taxes & fees
31 Jan - 1 February 2025
Valley Cabin
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.