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Find All Southeast Missouri Hotels
We have found 563 Southeast Missouri Hotels
- The Woods and Willow Room. 2 queen beds and grab-n-go breakfast items
- Cabin Springs. Escape to the quiet country. Fish, hike, kayak, see the stars.
- Secluded Upper Ozarks Farmhouse in Ozarks Mountains
- Secluded 5-Bedroom Lodge with Private Lake – Perfect for Large Groups!
- The Lodge @ Stormy Mountain Ranch Close drive to Emience and surrounding springs
- Private getaway on 4 acres-Close to lots of outdoor activities!
- Triangle Inn Motel
- Sam A Baker
- Alpaca Farm Stay
- Eagle's Landing River Resort
- SOLAR ECLIPSE! Lodge on10ac open field. 4 bed, 1 bath. Family/Pet friendly
- Sunnen Lodge YMCA Lofted Room | Meals Included
- Sunnen Center Room w/ Meals | Hike, Kayak & More!
- Charming 1-bedroom B&B with AC, WiFi in historic Cape Girardeau
- Relax with the whole family at Puckett’s View- Potosi
- YMCA Trout Lodge
- River City Casino & Hotel
- The Wildwood Hotel
- Best Western St. Louis-Kirkwood Route 66
- Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
- Forest Park Hotel by MDR
- Wingate by Wyndham St. Louis/Fenton Route 66
- Hilton St. Louis Frontenac
- Holiday Inn St. Louis West Six Flags by IHG
- Quality Inn & Suites near St. Louis and I-255
- Drury Inn & Suites St. Louis Forest Park
- Best Western St. Louis Inn
- Drury Inn & Suites St. Louis Brentwood
- Americas Best Value Inn St. Louis South
- Drury Inn & Suites Southwest St. Louis
- La Quinta Inn & Suites by Wyndham St Louis Route 66
- SpringHill Suites St. Louis Brentwood
- Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave
- Holiday Inn St Louis SW - Route 66 by IHG
- Pear Tree Inn St. Louis Arnold
- Baymont by Wyndham West Plains
- Comfort Inn Near Six Flags St. Louis
- Holiday Inn Blytheville by IHG
- Holiday Inn Express & Suites St. Louis South - I-55 by IHG
- TownePlace Suites by Marriott Brentwood
- Best Western Plus Fenton
- Holiday Inn Express & Suites West Plains Southwest by IHG
- Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
- Pinemark Inn & Suites
- Holiday Inn Express & Suites St. Louis West - Fenton by IHG
- Drury Inn & Suites St. Louis Arnold
- Super 8 by Wyndham Eureka/Six Flags Nearby
- Courtyard by Marriott St. Louis West County
- Baymont by Wyndham Sullivan
- Super 8 by Wyndham Union
- Super 8 by Wyndham St. Clair MO
- Hampton Inn & Suites St. Louis/South I-55
- Super 8 by Wyndham Sullivan
- Americas Best Value Inn Blytheville
- Days Inn & Suites by Wyndham Cuba
- Comfort Suites St. Louis - Sunset Hills
- The Lodge at Grant's Trail
- The Principal Hotel
- Comfort Inn Sullivan
- Quality Inn
- Residence Inn by Marriott St. Louis West County
- Holiday Inn Express Hotel & Suites Dyersburg by IHG
- Econo Lodge
- Quality Inn Near Six Flags St. Louis
- Extended Stay America Suites - St Louis - Fenton
- Hampton Inn West Plains
- Baymont by Wyndham Chester IL
- Hampton Inn St. Louis - Columbia
- Super 8 by Wyndham Cuba
- WoodSpring Suites St. Louis Arnold
- Days Inn by Wyndham Dyersburg
- Fairfield Inn & Suites by Marriott St. Louis South
- Quality Inn Dyersburg I-155
- Hampton Inn Blytheville
- Comfort Inn & Suites
- Hampton Inn St. Louis Southwest
- Americas Best Inn - Eureka
- Super 8 by Wyndham West Plains
- Super 8 by Wyndham Waterloo
- Sleep Inn & Suites Dyersburg I-155
- Hotel 7 Inn Anna
- Comfort Inn US 60/63
- Hampton Inn Dyersburg
- Country Inn Motel
- West Plains Motel
- For Larger Groups (Up To 24) Right on Reelfoot Lake--Private Dock And Pier
- Americas Best Value Inn Sullivan
- Motel 6 Dyersburg, TN
- Super 8 by Wyndham Blytheville
- Wine Country Farmhouse On the Wine 🍷 Trail! Private Lake kayaks Fire Pit 🔥
- Days Inn by Wyndham Blytheville
- Montauk Lodge
- OYO Hotel Blytheville AR I-55
- Motel 6 Sullivan, MO
- NEW property! Lakeside covered hot tub, A-frame 3 King Beds, Shawnee Forest
- Quality Inn Cairo I-57
- Premier lodging at Reelfoot lake , First class upgrade!