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Check availability on San Sisto 5 Star Hotels

Compare San Sisto 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Sina Brufani
Front of property

Sina Brufani

5.0 star property
9.2 out of 10, Wonderful, (576)
"Excellent service and location with a very friendly staff. "
The price is AED 709
AED 798 total
includes taxes & fees
20 Feb - 21 Feb
Sina Brufani
Relais Il Canalicchio
Exterior

Relais Il Canalicchio

4.0 star property
8.4 out of 10, Very Good, (113)
"First day dinner was great, on the second day not. We were waiting around 80 minutes our dinner to start, quality was not good at all vs the first day. The rest is ok. "
Relais Il Canalicchio
Monastero di Cortona Hotel & Spa
Lobby

Monastero di Cortona Hotel & Spa

5.0 star property
10.0 out of 10, Exceptional, (204)
"The inside and outside is beautiful. It overlooks the town of Cortona. The staff were fantastic. They treated us like we were part of their own families."
Monastero di Cortona Hotel & Spa
Fonteverde Lifestyle & Thermal Retreat
Infinity pool

Fonteverde Lifestyle & Thermal Retreat

5.0 star property
9.4 out of 10, Exceptional, (156)
"Beautiful Tuscan location and views "
The price is AED 1,103
AED 1,228 total
includes taxes & fees
2 Mar - 3 Mar
Fonteverde Lifestyle & Thermal Retreat
Precise Tale Poggio Alla Sala
Exterior

Precise Tale Poggio Alla Sala

5.0 star property
9.4 out of 10, Exceptional, (75)
"Everything and everyone was spot on. Driveway needs repair "
Precise Tale Poggio Alla Sala
TH Assisi - Hotel Cenacolo
Front of property - evening/night

TH Assisi - Hotel Cenacolo

4.0 star property
9.0 out of 10, Wonderful, (520)
"It was a good property close to Assisi. No complaints. Not 5 star but convenient walk to Assisi. "
The price is AED 242
AED 289 total
includes taxes & fees
26 Feb - 27 Feb
TH Assisi - Hotel Cenacolo
I Capricci di Merion Resort & Spa
Indoor pool

I Capricci di Merion Resort & Spa

4.0 star property
9.8 out of 10, Exceptional, (46)
"This property is so beautiful and the food at the resturant was fantastic. Our only complaint was the spa, the sauna was great, but the hottub was lukewarm and there was so much chlorine it made our eyes burn and we had to get out almost immediately. Otherwise a perfect experience!"
The price is AED 555
AED 611 total
includes taxes & fees
24 Feb - 25 Feb
I Capricci di Merion Resort & Spa
Altarocca Wine Resort Adults Only
Front of property

Altarocca Wine Resort Adults Only

9.6 out of 10, Exceptional, (269)
"I would come here again!"
The price is AED 423
AED 482 total
includes taxes & fees
23 Feb - 24 Feb
Altarocca Wine Resort Adults Only
Villa di Piazzano - Small Luxury Hotel of the World
Pool

Villa di Piazzano - Small Luxury Hotel of the World

5.0 star property
9.8 out of 10, Exceptional, (200)
"The Villa di Piazzano is stunning down to the smallest detail. The staff is attentive, pleasant and helpful. The food and wine at the onsite restaurant was some of the best we had on our 23-day trip across Italy. One of our favorite stays for sure!"
Villa di Piazzano - Small Luxury Hotel of the World
Albergo San Biagio
View from property

Albergo San Biagio

3.0 star property
8.6 out of 10, Excellent, (150)
"Location"
The price is AED 172
AED 204 total
includes taxes & fees
17 Feb - 18 Feb
Albergo San Biagio
Sagrantino Experience
Pool

Sagrantino Experience

9.8 out of 10, Exceptional, (6)
"We had a wonderful time staying at Maria Rosa’s as a family of 6 with 4 kids 11 & younger. It was a great price & had everything we needed for a week long stay. It was a nice place to use as a home base for exploring the area of Umbria (Don’t miss Assisi! It is amazing!) There was a well loved pool table & foosball table that our kids greatly enjoyed. We were able to cook with all the pots & pans we needed & the water was hot for showers. Keep in mind you definitely need a car & this is a well...
The price is AED 227
AED 390 total
includes taxes & fees
13 Feb - 14 Feb
Sagrantino Experience
Hotel Sangallo Palace
Room

Hotel Sangallo Palace

4.0 star property
8.8 out of 10, Excellent, (549)
"Great place "
The price is AED 409
AED 465 total
includes taxes & fees
16 Feb - 17 Feb
Hotel Sangallo Palace
Chocohotel
Breakfast area

Chocohotel

3.0 star property
8.8 out of 10, Excellent, (464)
"Great servive, novel theme"
The price is AED 327
AED 372 total
includes taxes & fees
16 Feb - 17 Feb
Chocohotel
Villa Svetoni Wine Resort
Exterior

Villa Svetoni Wine Resort

10.0 out of 10, Exceptional, (25)
"Perfect place ! Comfortable ! Clean ! Beautiful "
The price is AED 767
AED 859 total
includes taxes & fees
16 Feb - 17 Feb
Villa Svetoni Wine Resort
Hotel Priori Secret Garden
Terrace/patio

Hotel Priori Secret Garden

4.0 star property
9.6 out of 10, Exceptional, (123)
"We had a perfect stay. Thank you!"
The price is AED 573
AED 645 total
includes taxes & fees
13 Feb - 14 Feb
Hotel Priori Secret Garden
Il Palazzo
View from room

Il Palazzo

3.0 star property
9.6 out of 10, Exceptional, (403)
"E had a great stay at Il Palazzo. The property is beautiful and historic and conveniently located near all the beautiful attractions. Assisi is absolutely stunning."
Il Palazzo
Lupaia
Aerial view

Lupaia

10.0 out of 10, Exceptional, (67)
"Magnificent Lupaia will forever remain a dream holiday for us in the most beautiful, serene and picturesque location. The scent of jasmine and rose covered cottages surrounded by lush green gardens and idyllic vistas are what dreams are made off. Warm, welcoming staff can’t do enough to make your stay a delight. Many thanks to all at Lupaia. "
The price is AED 2,752
AED 3,035 total
includes taxes & fees
14 Mar - 15 Mar
Lupaia
AgriHotel Villa Ambra
View from property

AgriHotel Villa Ambra

3.0 star property
9.2 out of 10, Wonderful, (141)
"It was only 10 min away driving from Montepulciano town. The hotel was clean and comfortable, had also a charger station for electric cars, the receptionist was very friendly! "
AgriHotel Villa Ambra
Giotto Hotel & Spa
Indoor spa tub

Giotto Hotel & Spa

4.0 star property
8.8 out of 10, Excellent, (659)
"The Hotel is well located "
The price is AED 1,127
AED 1,262 total
includes taxes & fees
18 Feb - 19 Feb
Giotto Hotel & Spa
Relais Il Falconiere
Exterior

Relais Il Falconiere

5.0 star property
9.4 out of 10, Exceptional, (96)
"Stunning property with an amazing restaurant. "
Relais Il Falconiere
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Frequently asked questions

What are the best 5-star hotels in San Sisto?
According to Expedia traveler reviews, Sina Brufani, Hotel Le Tre Vaselle and Borgobrufa Spa Resort Adults Only are some of the leading 5-star hotels in San Sisto. Offering best-in-class amenities and unparalleled service, you’ll enjoy an opulent and comfortable stay.
How much does it cost to stay in a 5-star hotel in San Sisto?
The amount you pay for a 5-star hotel in San Sisto depends on things such as when you plan to go and the length of your getaway. Our top tip for landing the best deal? Use our pricing filters to check out the available hotels for your preferred dates.

  • Search for the lowest price per night

What makes a hotel 5 stars in San Sisto?
Flawless guest service is integral to every 5-star hotel in San Sisto. From the minute you arrive, staff are at your beck and call, whether offering luggage assistance and storage or providing in-room massages. Plus, hotels must offer upscale conveniences to qualify for a 5-star rating. These can include deluxe baths, an on-site spa, pools, gastronomic kitchens and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in San Sisto?
Use our handy filters to find an upmarket getaway in San Sisto where everything you need is included in the price. From there, refine your results for hotels that have a 5-star rating and are listed as “All inclusive.” The first thing on the itinerary at these stays? Pure enjoyment and indulgence.
What are the top 5-star spa hotels in San Sisto?
Spoil yourself with a decadent massage and other restorative treatments at Borgobrufa Spa Resort Adults Only. It’s one of San Sisto’s premier 5-star spa properties. Hotel Le Tre Vaselle and Sina Brufani also combine upmarket accommodations with wellness experiences.
Are there any 5-star vacation rentals in San Sisto?
Our site doesn’t offer any 5-star vacation rentals in San Sisto. However, you can still find a few top-rated retreats where the only item on your itinerary will be to unpack and have fun. See what’s available by browsing our vacation rentals in San Sisto.
Are there any 5-star hotels in downtown San Sisto?
Discover downtown San Sisto from Sina Brufani. Check in to this 5-star hotel and enjoy easy access to some fun things to do and see.