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De Soto Hotels by Star Rating
Stay near popular De Soto attractions
- Hotels near Mississippi River
- Hotels near Meramec State Park
- Hotels near Meramec River
- Hotels near Bonne Terre Mine
- Hotels near Pickle Springs Natural Area
- Hotels near Hawn State Park
- Hotels near St. Joe State Park
- Hotels near Big River
- Hotels near St. Francois State Park
- Hotels near Crown Pointe Golf Club
- Hotels near Washington State Park
- Hotels near Villa Antonio Winery
Explore more hotels
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
- Super 8 by Wyndham Bonne Terre
- Quality Inn Farmington
- Postcard Cabins St. Francois
- Crown Pointe Lodge, BW Signature Collection
- Hampton Inn Farmington
- WoodSpring Suites St. Louis Arnold
- Super 8 by Wyndham Potosi
- Holiday Inn Express & Suites Farmington by IHG
- Lake Haven - Updated Mid Century Cabin Only 35 Mins from St. Louis
- Quality Inn Festus
- Cute Ranch -safe and quiet- 1800 sft living space
- Treehouse and Hot Tub on 10acres - Pet Friendly!
- Cozy country setting 4 miles from route 66
- Charming 1-bedroom house in nice Imperial with AC. Attn! Traveling Contractors
- Serenity Log Inn -Log out and Log Inn to Serenity
- The Conner House B&B
- Cute town house -3 Queen beds
- Cabin 1 at the Pallet Factory
- Nice big Ranch home - safe & quiet -0.5 acre lot