Find 4 Star Hotels in Affton, MO
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Affton 4 Star Hotels
Compare Affton 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch
8.4 out of 10, Very Good, (3870)
The price is AEDĀ 386
AEDĀ 455 total
includes taxes & fees
18 Apr - 19 Apr

Moonrise Hotel
Moonrise Hotel
9.0 out of 10, Wonderful, (1840)
The price is AEDĀ 509
AEDĀ 605 total
includes taxes & fees
15 Apr - 16 Apr

River City Casino & Hotel
River City Casino & Hotel
9.0 out of 10, Wonderful, (1280)
The price is AEDĀ 323
AEDĀ 430 total
includes taxes & fees
6 Apr - 7 Apr

DoubleTree by Hilton St. Louis Airport
DoubleTree by Hilton St. Louis Airport
7.8 out of 10, Good, (696)
The price is AEDĀ 418
AEDĀ 491 total
includes taxes & fees
6 Apr - 7 Apr

21C Museum Hotel St Louis
21C Museum Hotel St Louis
9.2 out of 10, Wonderful, (1033)
The price is AEDĀ 592
AEDĀ 710 total
includes taxes & fees
16 Apr - 17 Apr

Renaissance St. Louis Airport Hotel
Renaissance St. Louis Airport Hotel
8.2 out of 10, Very Good, (1181)
The price is AEDĀ 433
AEDĀ 507 total
includes taxes & fees
26 Apr - 27 Apr

Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
8.4 out of 10, Very Good, (1134)
The price is AEDĀ 621
AEDĀ 787 total
includes taxes & fees
13 Apr - 14 Apr

Live by Loews - St.Louis
Live by Loews - St.Louis
9.2 out of 10, Wonderful, (1127)
The price is AEDĀ 584
AEDĀ 695 total
includes taxes & fees
6 Apr - 7 Apr
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Affton
Love dining out and sports? Get away to Affton!
Recent reviews of Affton hotels
Recent reviews of Affton hotels

River City Casino & Hotel
5/5 Excellent
"Staff was very kind. The room was very clean and the food was great. "
A verified traveler stayed at River City Casino & Hotel
Posted 15 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Affton Hotels by Star Rating
Stay near popular Affton attractions
- Hotels near Busch Stadium
- Hotels near St. Louis Union Station
- Hotels near Gateway Arch
- Hotels near St. Louis Zoo
- Hotels near Enterprise Center
- Hotels near Washington University in St. Louis
- Hotels near Forest Park
- Hotels near Six Flags St. Louis
- Hotels near City Museum
- Hotels near Barnes Jewish Hospital
- Hotels near America's Center Convention Complex
- Hotels near St. Louis University
- Hotels near Dome at Americaās Center
- Hotels near Fox Theater
- Hotels near Ameristar Casino St. Charles
- Hotels near Hollywood Casino Amphitheatre
- Hotels near Mississippi River
- Hotels near Westport Plaza
- Hotels near Horseshoe St. Louis Casino
- Hotels near St Charles Convention Center
Explore more hotels
- 21C Museum Hotel St Louis
- Drury Inn & Suites St. Louis Union Station
- Live by Loews - St.Louis
- Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
- Embassy Suites by Hilton St. Louis Downtown
- Ameristar Casino Resort and Spa
- The Wildwood Hotel
- Casino Queen Hotel
- St. Louis Union Station Hotel, Curio Collection by Hilton
- Hilton St. Louis at the Ballpark
- Best Western St. Louis-Kirkwood Route 66
- Renaissance St. Louis Airport Hotel
- Hampton Inn St. Louis-Downtown (At the Gateway Arch)
- La Quinta Inn & Suites by Wyndham St. Louis Westport
- Pear Tree Inn St. Louis Airport
- The West End
- DoubleTree by Hilton St. Louis Airport
- Days Inn and Suites by Wyndham St. Louis/Westport Plaza
- The Cheshire
- Wingate by Wyndham St. Louis/Fenton Route 66