Upstate South Carolina Vacations

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Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville featuring autumn leaves, a garden and a bridge

Greenville Downtown

2 out of top 10 points of interest in this area
5/5(654 area reviews)

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Find hotels in Greenville Downtown

Find the Best Upstate South Carolina Vacation Packages

Upstate South Carolina Hotel Deals

Hyatt Regency Greenville
Hyatt Regency Greenville
3.5 out of 5
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is AED 496 per night from Apr 20 to Apr 21
AED 496
AED 562 total
includes taxes & fees
20 Apr - 21 Apr
8.6/10 Excellent! (1,000 reviews)
"Very slow check in, probably just a little screwup on them. Mgt was all over the situation when it became apparent."

Reviewed on 31 March 2025

Hyatt Regency Greenville
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
3.5 out of 5
851 Congaree Rd, Greenville, SC
Fully refundable
The price is AED 364 per night from Apr 6 to Apr 7
AED 364
AED 400 total
includes taxes & fees
6 Apr - 7 Apr
8.4/10 Very Good! (1,000 reviews)
"Clean room, breakfast is okay"

Reviewed on 1 April 2025

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Hyatt Place Greenville/Downtown
Hyatt Place Greenville/Downtown
3 out of 5
128 East Broad Street, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is AED 452 per night from Apr 20 to Apr 21
AED 452
AED 512 total
includes taxes & fees
20 Apr - 21 Apr
9/10 Wonderful! (1,012 reviews)
"Well maintained hotel in great walking distance to everything"

Reviewed on 1 April 2025

Hyatt Place Greenville/Downtown
See all 2,597 properties in Upstate South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Upstate South Carolina

Clemson University

Clemson University

5/5(410 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

Clemson University
Falls Park on the Reedy

Falls Park on the Reedy

4.5/5(583 reviews)

Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

Falls Park on the Reedy
Lake Keowee is a man–made reservoir in the United States in the state of South Carolina. It was created to serve the needs of a power utility as well as public recreational purposes. One of my favorite places to go in the summer. The water really is that color.

Lake Keowee

4.5/5(101 reviews)

Commune with nature and explore the great outdoors at Lake Keowee during your travels in Salem. While you're in the area, wander around the college campus.

Lake Keowee