Southern Illinois Vacations
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Where to stay in Southern Illinois
Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois
Eastport
If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.
Find the Best Southern Illinois Vacation Packages
Southern Illinois Hotel Deals
Drury Plaza Hotel Mt. Vernon
145 North 44th Street , Mount Vernon, IL
Fully refundableReserve now, pay when you stay
The price is AED 430 per night from Apr 27 to Apr 28
AED 430
AED 484 total
includes taxes & fees
27 Apr - 28 Apr
9.6/10 Exceptional! (1,291 reviews)
"Staff was very friendly and attentive!"
Reviewed on 17 April 2025
Super 8 by Wyndham O'Fallon
1100 Eastgate Dr, O'Fallon, IL
Fully refundableReserve now, pay when you stay
The price is AED 190 per night from Apr 27 to Apr 28
AED 190
AED 219 total
includes taxes & fees
27 Apr - 28 Apr
7.6/10 Good! (1,002 reviews)
"service was very friendly. easy location very dated but was clean reasonable place to stay out the storms as we were traveling"
Reviewed on 12 April 2025
Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Dr, East St. Louis, IL
Fully refundableReserve now, pay when you stay
The price is AED 247 per night from Apr 27 to Apr 28
AED 247
AED 279 total
includes taxes & fees
27 Apr - 28 Apr
7.4/10 Good! (1,001 reviews)
"Weight room was kinda limited. The pool Was nice!"
Reviewed on 18 April 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Southern Illinois
Southern Illinois University
4.5/5(173 reviews)
Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.
Garden of the Gods Recreation Area
5/5(6 reviews)
Explore the great outdoors at Garden of the Gods Recreation Area, a lovely green space in Equality. While you're in the area, stroll along the riverfront.
Cahokia Mounds State Historic Site
4.5/5(4 reviews)
You can learn about the history of Collinsville when you stop by Cahokia Mounds State Historic Site. Discover the great live music in this walkable area, or seek out the local tours.