Southeastern Indiana Vacations

Book a Hotel + Flight together to unlock savings

  • Plan, book, travel with confidence

    • payments icon
    Better together
    Save up to AED 148 when you book a flight and hotel together*
    lob hotels icon
    Find the right fit
    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon
    Rest easy
    Plan, book, and manage your trip all in one place

Where to stay in Southeastern Indiana

Find the best Southeastern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southeastern Indiana
Louisville Science Center featuring outdoor art

West Main Historic District

Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.

Find hotels in West Main Historic District

Find the Best Southeastern Indiana Vacation Packages

Southeastern Indiana Hotel Deals

Radisson Hotel Louisville North
Radisson Hotel Louisville North
3 out of 5
505 Marriott Drive, Clarksville, IN
Fully refundable
The price is AED 212 per night from Mar 30 to Mar 31
AED 212
AED 240 total
includes taxes & fees
30 Mar - 31 Mar
6.8/10 (1,925 reviews)
"Great location!! Great value for the price!!"

Reviewed on 23 March 2025

Radisson Hotel Louisville North
Comfort Inn & Suites Clarksville - Louisville North
Comfort Inn & Suites Clarksville - Louisville North
2.5 out of 5
1485 Broadway St, Clarksville, IN
Fully refundableReserve now, pay when you stay
The price is AED 340 per night from Apr 6 to Apr 7
AED 340
AED 385 total
includes taxes & fees
6 Apr - 7 Apr
8.8/10 Excellent! (810 reviews)
"Only lost a star because of the smoky scent in the toilet area and talking sounds from other rooms when trying to sleep after 12am"

Reviewed on 22 March 2025

Comfort Inn & Suites Clarksville - Louisville North
Sheraton Louisville Riverside by Marriott
Sheraton Louisville Riverside by Marriott
3.5 out of 5
700 West Riverside Drive, Jeffersonville, IN
Fully refundableReserve now, pay when you stay
The price is AED 320 per night from Apr 20 to Apr 21
AED 320
AED 361 total
includes taxes & fees
20 Apr - 21 Apr
8/10 Very Good! (1,000 reviews)
"Great place"

Reviewed on 16 March 2025

Sheraton Louisville Riverside by Marriott
See all 1,031 properties in Southeastern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Southeastern Indiana

Louisville Slugger Museum showing interior views

Louisville Slugger Museum

4.5/5(606 reviews)

You can spend an afternoon browsing the exhibits at Louisville Slugger Museum during your travels in Louisville. Amble around the area's riverfront or attend a sporting event.

Louisville Slugger Museum
Helped celebrate the Belle of Louisville's 100th birthday with a cruise up the Ohio River.

Louisville Waterfront Park

4.5/5(301 reviews)

After visiting Louisville Waterfront Park, make a plan to see the other sights and activities in Louisville. Stroll along the area's riverfront or experience its acclaimed theater scene.

Louisville Waterfront Park
Doc Crow's is perfect downtown spot for brisket and barbeque and has the tastiest drinks, especially the Man on Fire

Whiskey Row

Find out about the history of Louisville when you spend time at Whiskey Row. Attend a sporting event or simply enjoy the lively bars while you're in the area.

Whiskey Row