South Central Houston Vacations

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Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most. Learn more about South Central Houston
Discovery Green which includes a city, central business district and a high rise building

Downtown Houston

3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

Find hotels in Downtown Houston

South Central Houston Hotel Deals

Hotel Zaza Houston Museum District
Hotel Zaza Houston Museum District
4.5 out of 5
5701 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AED 840 per night from Mar 9 to Mar 10
AED 840
AED 1,133 total
includes taxes & fees
9 Mar - 10 Mar
8.8/10 Excellent! (1,599 reviews)
Incredible service
"I always enjoy staying at Zaza in Museum district as I love walking to the museums. This trip I had a flat tire that was punctured by a nail, the concierge took care of it and it was fixed during my one night stay. I arrived after 5 pm and all tire shops near by were already closed. This was an experience ..."

Reviewed on 28 February 2025

Hotel Zaza Houston Museum District
Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical Center
3.5 out of 5
6633 Travis St, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AED 398 per night from Mar 23 to Mar 24
AED 398
AED 470 total
includes taxes & fees
23 Mar - 24 Mar
8.2/10 Very Good! (1,221 reviews)
"The breakfast options provided a variety of choices."

Reviewed on 28 February 2025

Hilton Houston Plaza/Medical Center
The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum District
4 out of 5
1709 DRYDEN ROAD, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AED 621 per night from Mar 16 to Mar 17
AED 621
AED 773 total
includes taxes & fees
16 Mar - 17 Mar
9/10 Wonderful! (1,004 reviews)
"Nice place to stay when you need to be close to MD Anderson for medical appointments"

Reviewed on 3 March 2025

The Westin Houston Medical Center/Museum District
See all 1,201 properties in South Central Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in South Central Houston

Rice University

Rice University

4.5/5(356 reviews)

Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's acclaimed theater scene and lively festivals.

Rice University
University of Houston

University of Houston

4/5(392 reviews)

Enjoy the collegiate vibe when you visit University of Houston, during your travels in Houston. Experience the lively festivals and acclaimed theater scene in this vibrant area.

University of Houston
Houston Zoo

Houston Zoo

4.5/5(998 reviews)

Why not visit the native and exotic animals at Houston Zoo and see why this is a popular attraction in Houston? Experience the area's fascinating museums and acclaimed theater scene.

Houston Zoo