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Compare 452 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

The Lodge at Wakulla Springs
3.0 star property
9.2 out of 10, Wonderful, (807)
"Mother nature at her best! Don't miss the boat, tour!"
The price is AED 437
AED 487 total
includes taxes & fees
2 Oct - 3 Oct
The Lodge at Wakulla Springs
Magnuson Hotel Wildwood Inn
3.0 star property
8.6 out of 10, Excellent, (1001)
"We liked being in the country."
The price is AED 435
AED 490 total
includes taxes & fees
13 Oct - 14 Oct
Magnuson Hotel Wildwood Inn
Best Western Wakulla Inn & Suites
2.5 star property
8.8 out of 10, Excellent, (841)
"Na"
The price is AED 379
AED 416 total
includes taxes & fees
23 Oct - 24 Oct
Best Western Wakulla Inn & Suites
The Panacea Motel
2.0 star property
9.4 out of 10, Exceptional, (43)
"Lovely retro-style motel with updated fixtures."
The Panacea Motel
Cozy Spring Creek Cottage, fishing, hunting, relaxing in nature's coast.
9.8 out of 10, Exceptional, (21)
"We went to Crawfordville on short notice. The hosts were quick to respond. The property was clean and we had a great stay."
The price is AED 404
AED 956 total
includes taxes & fees
29 Sep - 30 Sep
Cozy Spring Creek Cottage, fishing, hunting, relaxing in nature's coast.
Shell Point Beach! Newly Renovated, Bay, Beach, Pool, Fishing, Dock, Golf Cart!
9.0 out of 10, Wonderful, (80)
"Great stay!! We never got to access a working golf cart, but we had a great time regardless! "
Shell Point Beach! Newly Renovated, Bay, Beach, Pool, Fishing, Dock, Golf Cart!
CONDO Water front, bay breeze, fishing paradise and family friendly 2 bedroom
9.4 out of 10, Exceptional, (85)
"It was a very nice place in a nice, quiet area. We loved it! "
CONDO Water front, bay breeze, fishing paradise and family friendly 2 bedroom
Shell Point Beach 2BR condo with marina views
10.0 out of 10, Exceptional, (8)
"We stayed at this property while visiting Tallahassee for an FSU game, and found this gem about 40 minutes away from the stadium. The property is at the top of what seems to be an apartment complex with about 7 other units with tenants. It is a small unit, with a very cohesive interior design with beautiful updated fixtures. The unit itself was very clean and tidy. The inside space is a bit on the small side, but there is a very good use of space. The surrounding area was very quiet and peaceful...
The price is AED 628
AED 1,008 total
includes taxes & fees
29 Sep - 30 Sep
Shell Point Beach 2BR condo with marina views
Enjoy Crawfordville downtown convenience at the Courtyard’s Pelican Cottage.
10.0 out of 10, Exceptional, (94)
"Very clean, great location, and loved the bottled water, beer in the fridge and the docking stations in the bedrooms. Thanks for a great stay."
The price is AED 320
AED 676 total
includes taxes & fees
30 Sep - 1 Oct
Enjoy Crawfordville downtown convenience at the Courtyard’s Pelican Cottage.
The Tranquil Trio - WiFi, Firepit, Full Kitchen, Netflix, Theatre Seats & More!
10.0 out of 10, Exceptional, (3)
"Cute house to stay in "
The price is AED 735
AED 1,138 total
includes taxes & fees
29 Sep - 30 Sep
The Tranquil Trio - WiFi, Firepit, Full Kitchen, Netflix, Theatre Seats & More!
Crawfordville Town Center convenience at the Courtyard’s Oyster Cottage
10.0 out of 10, Exceptional, (25)
"The Oyster Cottage is so adorable! So well decorated - love the oyster theme! The cottage was so well stocked, clean, the owners are terrific and very communicative, and everything was just spectacular in every sense! THANK YOU for a fabulous stay! The Heard Family "
The price is AED 386
AED 757 total
includes taxes & fees
30 Sep - 1 Oct
Crawfordville Town Center convenience at the Courtyard’s Oyster Cottage
Peace on the river. Wakulla springs nearby. Wakulla River adjoins property’.
10.0 out of 10, Exceptional, (18)
"Really enjoyed our stay. Surrounded by woods, the only sounds were birds and crickets. Watched the deer in the mornings and evenings."
Peace on the river. Wakulla springs nearby. Wakulla River adjoins property’.
Centrally located to fishing, biking, hiking, beaches, and seafood restaurants.
2.0 star property
10.0 out of 10, Exceptional, (3)
"The house was very charming and very clean you have everything that would need or want for your stay. The host was very hands on and will text you back if you need to asked a question or need something my best stay yet. Hope to be able to come back and stay again soon."
Centrally located to fishing, biking, hiking, beaches, and seafood restaurants.
Dragonfly on the Canal
2.0 star property
10.0 out of 10, Exceptional, (3)
"We had a great time fishing and boating. Location is great. Easy access to Oyster Bay. The house is nicely furnished and clean. Quite neighborhood. The owners are quick to respond to any questions. "
The price is AED 569
AED 1,275 total
includes taxes & fees
29 Sep - 30 Sep
Dragonfly on the Canal
Relax on a Beautiful River in a Natural Florida Setting
10.0 out of 10, Exceptional, (212)
"If peace and quiet is your goal, this is the place for you. Due to rain every day of our stay, we weren't able to take advantage of the nearby hiking trails (many of them identified in the cabin's welcome binder). Carolyn is an amazing hostess with great communications and a knack to foresee your needs. We highly recommend this property."
Relax on a Beautiful River in a Natural Florida Setting
Reel Pelican Paradise located in Paradise village, Shellpoint Beach on the Gulf
10.0 out of 10, Exceptional, (61)
"Well this was a very comfortable and homey place. We played cards outside and enjoyed the sunsets over the water. The kitchen was very nice and they had an area just for computers - all set up. The bedrooms and bathrooms were all very nice and spacious. We walked the neighborhood, rode bike and also went to the archeological sites in St. Mary's / Wakulla. I would come back here any day and recommend to others."
The price is AED 305
AED 947 total
includes taxes & fees
29 Sep - 30 Sep
Reel Pelican Paradise located in Paradise village, Shellpoint Beach on the Gulf
Perfect Getaway
10.0 out of 10, Exceptional, (35)
"Beautiful house , furnished really well. It was a quiet getaway we needed. Make sure you have plenty of bug spray . The mosquitoes will eat you alive!"
Perfect Getaway
7 Bedroom Beach House with POOL!! Gulf Front and Bay Front
10.0 out of 10, Exceptional, (111)
"We loved the house! Perfect for a large family. The owners have though of everything from pool floats to beach chairs to a crock pot! The pool is an added bonus and the close walk to the Tiki Hut makes for a fun afternoon. Loved our stay. "
The price is AED 2,938
AED 7,142 total
includes taxes & fees
12 Oct - 13 Oct
7 Bedroom Beach House with POOL!! Gulf Front and Bay Front
Family friendly home on 2 acres close to the beautiful beaches
10.0 out of 10, Exceptional, (2)
"My husband, three adult children, and granddaughter stayed here and had plenty of room for all of us. We enjoyed the outside space and the fire pit for roasting marshmellows. Everything was great, we only stayed one night but found this home to be very clean, relaxing, and family friendly. Tammy is a wonderful host!!"
The price is AED 826
AED 1,383 total
includes taxes & fees
29 Sep - 30 Sep
Family friendly home on 2 acres close to the beautiful beaches
Connie's Cottage- "The Hemingway" - Vintage Chic
10.0 out of 10, Exceptional, (29)
"Connie is the most gracious hostess I have encountered in our vacation rental experiences! When Tallahassee accommodations failed us for FSU Family Weekend, I broadened our search to include Panacea and I am so glad I did! Connie's communication before, during and after our stay was excellent and she truly thought of every detail when furnishing and stocking her cottage for her guests. We didn't cook during our quick weekend stay, but the kitchen was very well equipped for anything we would have...
Connie's Cottage- "The Hemingway" - Vintage Chic
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Frequently asked questions

Where is the best place to stay in Panacea?

Expedia customers give high marks to The Panacea Motel. See all available top hotels, or vacation rentals in Panacea.

What's the top vacation rental in Panacea?

7 Bedroom Beach House with POOL!! Gulf Front and Bay Front: Visitors give good reviews to this Panacea vacation home rental, which is located on the beach and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 7 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a garden and a selection of games. Other favorite homes for rent in Panacea are Beachfront bungalow with private direct beach access. Sleeps 8. Pet friendly! and Charming Alligator Point "Old Florida” Beach Cottage . See all vacation rentals in Panacea.

If I need to cancel my hotel reservation in Panacea, will I receive a refund?

Yes! Most hotel bookings are refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Panacea.

Where can I learn more about changing or cancelling my trip to Panacea?

For more details about changing or cancelling your trip to Panacea, click here.

What's the best pet-friendly place to stay in Panacea?

The Panacea Motel is a top pet-friendly option for your stay. See more pet-friendly hotel accommodations in Panacea.

What are some accommodations with pools in Panacea?

7 Bedroom Beach House with POOL!! Gulf Front and Bay Front: Offers complimentary wireless internet access, a pool, and kitchens. View all hotels with pools in Panacea.

What's the best hotel for staying near Tallahassee Regional Airport (TLH)?

Tallahassee Sun & Moon is one of the top choices for your stay and is a popular property, featuring free WiFi and free parking. It's located 3.5 mi (5.7 km) from Tallahassee Regional Airport. Other options close to the airport include Hampton Inn & Suites Tallahassee Capitol-University and Governors Inn.

What's it like to stay in Panacea?

Nature enthusiasts will enjoy exploring Panacea, and many visitors are sure to appreciate the beaches and seafood restaurants. The relaxing and tucked away setting also entices those visiting the city. In Panacea, there are 169 hotels and other accommodations to choose from. Find out more about Panacea.

What are the top places to visit in Panacea?

Natural beauty is on display at Mashes Sand Beach, Alligator Point Beach, and Bald Point State Park. Dolphin watching is a great activity, and Bayside Marina is one place to visit. A couple of additional sights to add to your agenda are Panacea Springs and Wilson Beach. Check out what more to see and do in Expedia's Panacea guide.

What's the seasonal weather like in Panacea?

The hottest months are usually July and August with an average temp of 81°F, while the coldest months are January and February with an average of 58°F. The rainiest months in Panacea are August, July, June, and September, with each month seeing an average of 8 inches of rainfall.