Find Business Hotels in Main Street Hyannis, MA

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Pick from 4 Main Street Hyannis Business Hotels and compare room rates, reviews, and availability. Most hotels are fully refundable.

Hyannis Plaza Hotel
2.5 star property
6.8 out of 10, (672)
"I paid online for the weekend and then an additional amount that I didn’t know about when checking in and I was told that it would be back in my account Monday morning and have not received it yet. "
The price is AED 275
AED 346 total
includes taxes & fees
15 Dec - 16 Dec
Hyannis Plaza Hotel
Comfort Inn Hyannis - Cape Cod
2.5 star property
7.6 out of 10, Good, (1003)
"Have stayed here many times. It is always quiet and comfortable."
The price is AED 335
AED 383 total
includes taxes & fees
29 Nov - 30 Nov
Comfort Inn Hyannis - Cape Cod
Americas Best Value Inn & Suites Hyannis Cape Cod
2.0 star property
7.6 out of 10, Good, (1002)
"Cute beachy stay in the heart of Hyannis! Super walkable and near the harbor!"
Americas Best Value Inn & Suites Hyannis Cape Cod
Cape Cod Inn
2.0 star property
8.8 out of 10, Excellent, (422)
"The Cape Cod Inn is a decent motel. The rooms are clean and spacious and quiet. We found it very convenient to park outside our door. It’s a very short walk to restaurants and shops and a ten minute walk to the ferry to either Nantucket or Martha’s Vineyard. Good value for the money, would definitely stay again. "
Cape Cod Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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