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Compare 15 Vacation Homes in Lake City with updated reviews, rates, and availability.

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
10.0 out of 10, Exceptional, (10)
"10/10 highly recommend if your in the area and need a place to stay. Very comfy, cozy and at home feel. "
The price is AED 654
AED 1,107 total
includes taxes & fees
17 Nov - 18 Nov
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
Quaint Bungalow in Historic Downtown Florence
10.0 out of 10, Exceptional, (11)
"The pictures on the VRBO app does not do this charming home justice, upon arrival the pink door alone was inviting but after opening the door, the oooh’s and the ahhhh’s started! You walk in and you are grinning from ear to ear the decor of this crafted 1930’s home was so beautiful, the hosts went into to great detail remodeling and updating the home but keeping it simple with clean lines and colors the decorator needs to teach me this skill! I did take pictures of everything I liked! The beds...
Quaint Bungalow in Historic Downtown Florence
Cozy 4-bedroom house with WiFi, AC in charming Florence
2.0 star property
7.0 out of 10, Good, (2)
"Excellent accommodations,. More than satisfied. "
Cozy 4-bedroom house with WiFi, AC in charming Florence
Cheerful home with plenty of privacy and entertainment room.
8.4 out of 10, Very Good, (19)
"Spacious home, with plenty of room for 6 adults. Just a heads-up, there's a sweet cat on the property. We found out a couple of days before, and let the owner know we had someone with a severe allergy. They made sure she wasn't able to come in the house, and we didn't have any trouble with reactions inside. The kitchen could use an update, but we there are plenty of dishes, utensils and spices available. Located on the edge of town, but still near plenty of food and grocery options. Having the...
Cheerful home with plenty of privacy and entertainment room.
Hickory Haven 3Br Elegant Downtown Hidden Gem
9.4 out of 10, Exceptional, (12)
"Our stay in Florence at this VRBO was simply amazing! Cleanliness was 10/10. Amenities were great! It was fully stocked . Game room was an added plus! It was comfortable and very well decorated and very well put together for the comfort of all who desires a home filled environment. The character of this home was superb! My family and I really enjoyed ourselves! We will definitely choose to stay here again . Host communication was excellent! Check in and out was easy an convenient."
Hickory Haven 3Br Elegant Downtown Hidden Gem
Pineapple House: Historic. Southern Charm. Walk Downtown.
9.4 out of 10, Exceptional, (13)
"The property was very clean and had nice decor. Bed was very comfortable and liked that there was a lot of towels for us to use. Communication with the host was excellent. They responded right away to our questions prior to check in. Check in was a breeze. The kitchen had everything we needed. The note from the host was a nice surprise. Location was convenient in that it was close to restaurants and the hospital. Neighborhood was quiet."
Pineapple House: Historic. Southern Charm. Walk Downtown.
Walking distance from one of South Carolina's top Medical centers.
9.8 out of 10, Exceptional, (31)
"Great accommodations and thoughtful details. Absolutely loved it!"
The price is AED 426
AED 777 total
includes taxes & fees
2 Dec - 3 Dec
Walking distance from one of South Carolina's top Medical centers.
Great Home in the Greater Florence Area
10.0 out of 10, Exceptional, (3)
"It was great but we just had trouble figuring out the tv"
Great Home in the Greater Florence Area
Townhouse in Florence SC closed to MUSC medical center.
Townhouse in Florence SC closed to MUSC medical center.
Comfy Townhome~ Modern Farmhouse with Full Office!
10.0 out of 10, Exceptional, (2)
"I had a very nice stay in Florence at this property. I was working from home through the week and the office setup was perfect."
Comfy Townhome~ Modern Farmhouse with Full Office!
2B/1.5 Bath Brand new Townhouse Closed to MUSC
2.0 star property
10.0 out of 10, Exceptional, (1)
"Great property, very clean and everything you need is provided. "
2B/1.5 Bath Brand new Townhouse Closed to MUSC
Luxury stay at 4 bedroom house
9.0 out of 10, Wonderful, (2)
"We went to Florence for a family reunion and wanted a place close by. The house is fine but slightly strange in its decor. It's perfectly fine, safe, and the host responds to questions very quickly,"
Luxury stay at 4 bedroom house
Work Friendly House Downtown Florence
Work Friendly House Downtown Florence
Charming 2 bedroom near downtown
Charming 2 bedroom near downtown
Charming Brand NEW 3B/2bathroom house closed by to all shopping and MUSC
2.0 star property
Charming Brand NEW 3B/2bathroom house closed by to all shopping and MUSC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Lake City

Cheerful home with plenty of privacy and entertainment room.
8.4 out of 10, Very Good, (19)
"Spacious home, with plenty of room for 6 adults. Just a heads-up, there's a sweet cat on the property. We found out a couple of days before, and let the owner know we had someone with a severe allergy. They made sure she wasn't able to come in the house, and we didn't have any trouble with reactions inside. The kitchen could use an update, but we there are plenty of dishes, utensils and spices available. Located on the edge of town, but still near plenty of food and grocery options. Having the...
Cheerful home with plenty of privacy and entertainment room.
Hickory Haven 3Br Elegant Downtown Hidden Gem
9.4 out of 10, Exceptional, (12)
"Our stay in Florence at this VRBO was simply amazing! Cleanliness was 10/10. Amenities were great! It was fully stocked . Game room was an added plus! It was comfortable and very well decorated and very well put together for the comfort of all who desires a home filled environment. The character of this home was superb! My family and I really enjoyed ourselves! We will definitely choose to stay here again . Host communication was excellent! Check in and out was easy an convenient."
Hickory Haven 3Br Elegant Downtown Hidden Gem
Oasis Located in the Heart of a Winery/ Halfway Point for Most Travelers
9.6 out of 10, Exceptional, (24)
"Spacing was nice and the set up of rooms coffee nook and walk in shower plus hot tub. Staff was very kind and helpful and walking areas for pet were great. Enjoyed the wine tasting and outside sitting area too."
The price is AED 459
AED 819 total
includes taxes & fees
7 Dec - 8 Dec
Oasis Located in the Heart of a Winery/ Halfway Point for Most Travelers
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.