Find Resorts & Hotels with Spas in Isle of Palms, SC

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Pick from 966 Isle of Palms Resorts & Hotels with Spas and compare room rates, reviews, and availability. Most hotels are fully refundable.

Wild Dunes Resort – Sweetgrass Inn and Boardwalk Inn

4.0 star property
8.8 out of 10, Excellent, (1011)
"My wife and I had an amazing time and cannot wait to return."
The price is AED 649
AED 892 total
includes taxes & fees
1 Dec - 2 Dec
Wild Dunes Resort – Sweetgrass Inn and Boardwalk Inn

The Palms Oceanfront Hotel

3.5 star property
8.2 out of 10, Very Good, (1012)
"This was my first time visiting this beautiful area. I wouldn’t hesitate to stay here again. Next time I’ll make sure to reserve a room with an ocean view. The staff is very friendly and informative. Dining and shopping is an easy short walk. "
The price is AED 480
AED 555 total
includes taxes & fees
26 Nov - 27 Nov
The Palms Oceanfront Hotel

Seaside Inn Oceanfront

2.5 star property
7.6 out of 10, Good, (1008)
"My daughter and I in town for her move to area. Hotel was great. Beachfront, on site parking available. Bars and restaurants in walking distance. Very safe. Hotel staff great. Elise helped me schedule our next trip there in 2 weeks. "
The price is AED 437
AED 507 total
includes taxes & fees
25 Nov - 26 Nov
Seaside Inn Oceanfront

OCEANFRONT / BELLA VISTA / POOL / SPA / ELEVATOR / NEWLY REMODELED

9.6 out of 10, Exceptional, (129)
"What a fabulous house! It was perfect for our group of ladies. Everything was beautiful, clean , and the location was perfect. "
OCEANFRONT / BELLA VISTA / POOL / SPA / ELEVATOR / NEWLY REMODELED

Port of Call on Isle of Palms ~ OCEAN FRONT, Pool, boardwalk, putting green

9.8 out of 10, Exceptional, (59)
"Overall experience was great. Only issues we had were the main kitchen sink had a bad leak at one point during the week. And 1 of the 2 dishwashers shorts out and did not work. Other than those it was a beautiful house. Would recommend to others. "
Port of Call on Isle of Palms ~ OCEAN FRONT, Pool, boardwalk, putting green

Oceanfront 1st Floor Condo!! Community Pool & Fishing Pier! Iin the Heart of IOP!

9.0 out of 10, Wonderful, (81)
"This was a great place for a quick weekend getaway. Very relaxing, and a lot of things within walking distance. "
The price is AED 390
AED 931 total
includes taxes & fees
25 Nov - 26 Nov
Oceanfront 1st Floor Condo!! Community Pool & Fishing Pier! Iin the Heart of IOP!

"Oceanfront 1BR & 1 Bath Villa. "Can't beat the late fall rates!"

9.0 out of 10, Wonderful, (220)
"Great for small families or big families for a few days. Awesome views, location and owner communication. Rent here. You wont regret it."
"Oceanfront 1BR & 1 Bath Villa. "Can't beat the late fall rates!"

Stunning Designer Home, Fully Renovated, in Gated Community Near Beach.

10.0 out of 10, Exceptional, (53)
"Home was exactly as in photos and much roomier than I expected. The kitchen is well appointed and the beds are comfortable. I would definitely recommend this rental. It was a girls weekend with 3 women but we had plenty of space for more!"
Stunning Designer Home, Fully Renovated, in Gated Community Near Beach.

Historical Beach House 5 BR 4 Bath with Private Pool

9.6 out of 10, Exceptional, (8)
"We enjoyed this home and all the amenities. The large spaces inside were great for family time and the pool and outdoor sitting area with the fireplace and tv allowed us to enjoy lots of fun while watching ball games and relaxing all at the same time. The close walk (3-5 minutes) to the beach was awesome as we did that every day. A beautiful home and a great community to spend time in. So fun. "
Historical Beach House 5 BR 4 Bath with Private Pool

Ocean Front - 3 Bedrooms, 3 Baths- Great View, Perfect Location!

9.6 out of 10, Exceptional, (187)
"The property is in a great location. The owner was very responsive to issues during our stay"
Ocean Front - 3 Bedrooms, 3 Baths- Great View, Perfect Location!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking to vacation at a spa hotel in Isle of Palms?
Forget the stress of everyday life and book yourself a hotel with a spa. Travelers love the beaches in Isle of Palms. Enjoy the live music and many popular restaurants during your vacation. Spa hotels are a great way to take a break from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Isle of Palms?
Wild Dunes Resort – Sweetgrass Inn and Boardwalk Inn is a top beach spa hotel featuring 5 pools, 8 restaurants, 9 bars, and a golf course. Enjoy a facial, body scrub, or detox wrap at The Spa at Sweetgrass. Another popular spa hotel in Isle of Palms is Wild Dunes Resort – Residences at Sweetgrass.
How many spa hotels will I find in Isle of Palms?
Among Expedia’s 1821 accommodation options in Isle of Palms, there are 2 spa hotels.
What's there to see and do in Isle of Palms?
Enjoy all that Isle of Palms has to offer and visit Isle of Palms Beach, Isle of Palms Marina, and Front Beach. If you have some spare time during your trip, you might want to check out Wild Dunes Resort Golf Course and Dewees Island Beach.
What is a Isle of Palms spa hotel?
Spa hotels in Isle of Palms provide lodging and have a full on-site spa which offers services like couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.